miR-141 Improve Osteoporosis by Promoting Osteoblast Differentiation through Targeting RICTOR

We investigated the regulatory roles of miR-141 and RICTOR genes in osteoporosis (OP) explored potential therapeutic value OP by targeting gene. The role as regulators ovariectomized (OVX) rats was determined using RT-qPCR assays models OVX rats. their expression levels related clinical features were further analyzed. functional miR-141/RICTOR pathway plasmids. lowly expressed rats, while gene highly expressed. Bioconductivity prediction analysis revealed sites for RICTOR. Promotion or inhibition mimic/ si-RNA reduced ALP activity well nuclear factor-kappa B ligand (RANKL), bone gla protein (BGP) tartrate resistant acid phosphatase (TRAP), promoting osteoprotegerin production. Healthy with elevated showed same symptoms OVX, whereas mimic injection improved Our data suggest that regulate osteoprotegerin, RANKL, BGP TRAP gene, impacting development OP.